PDF False Hope: Bone Marrow Transplantation for Breast Cancer

Description False Hope: Bone Marrow Transplantation for Breast Cancer

In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering. This book tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer, and fully explores the story's implications, which go well beyond the immediate procedure, and beyond breast cancer, to how we evaluate other medical procedures, especially life-saving ones. It details how the factors that drove clinical use - patient demand, physician enthusiasm, media reporting, litigation, economic exploitation, and legislative and administrative mandates - converged to propel the procedure forward despite a lack of proven clinical effectiveness. It also analyses the failure of the technology assessments and randomised clinical trials that evaluated the procedure and the ramifications of this flawed system on healthcare today. Sections of the book consider the initial conditions surrounding the emergence of the new breast cancer treatment, the drivers of clinical use, and the struggle for evidence-based medicine. A concluding section considers the significance of the story for our healthcare system.

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False Hope Bone Marrow Transplantation For Breast Cancer ~ False Hope: Bone Marrow Transplantation for Breast Cancer . False Hope Bone Marrow Transplantation for Breast Cancer Richard A. Rettig, Peter D. Jacobson, Cynthia M. Farquhar, M.D., and Wade M. Aubry, M.D. In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation

False Hope: Bone Marrow Transplantation for Breast Cancer ~ False Hope: Bone Marrow Transplantation for Breast Cancer. . particularly patients with breast cancer. Within a few years, several small, uncontrolled phase 1 and phase 2 studies, led .

False Hope: Bone Marrow Transplantation for Breast Cancer ~ False Hope: Bone Marrow Transplantation for Breast Cancer. Related Articles; The pioneering, Nobel Prize–winning work of E. Donnall Thomas in the 1960s and 1970s demonstrated that certain .

False Hope Bone Marrow Transplantation For Breast Cancer ~ False Hope Bone Marrow Transplantation for Breast Cancer Richard A. Rettig, Peter D. Jacobson, Cynthia M. Farquhar, M.D., and Wade M. Aubry, M.D. In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or

False Hope: Bone Marrow Transplantation for Breast Cancer ~ False Hope: Bone Marrow Transplantation for Breast Cancer Categories: E-Books & Audio Books 355 pages / English / ISBN-10: 0195187768 / ISBN-13: 9780195187762

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False Hope: Bone Marrow Transplantation for Breast Cancer ~ False Hope: Bone Marrow Transplantation for Breast Cancer: Authors: Richard A. Rettig, Peter D. Jacobson, Cynthia M. Farquhar M.D., Wade M. Aubry M.D. Publisher: Oxford University Press, 2007:.

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False Hope Bone Marrow Transplantation For Breast Cancer ~ 1960s false hope bone marrow transplantation for breast cancer english edition ebook richard a rettig peter d jacobson cynthia m md farquhar wade m md aubry false hope also analyzes the failure of the technology assessments and randomized clinical trials that evaluated the procedure and the ramifications of this flawed system on health

FALSE HOPE - The Eye ~ High-dose chemotherapy with autologous bone marrow transplantation (HDC/ABMT) emerged in the late 1980s as a promising new treatment for metastatic breast cancer, then for high-risk breast cancer. Its promise was based on high levels of complete and partial tumor response. In the 1990s, HDC/ABMT burst on the oncology scene and was

False Hope - Richard A. Rettig; Peter D. Jacobson; Cynthia ~ False Hope. Bone Marrow Transplantation for Breast Cancer. Richard A. Rettig, Peter D. Jacobson, Cynthia M. Farquhar, M.D., and Wade M. Aubry, M.D. Description. In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT.

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False Hope: Bone Marrow Transplantation for Breast Cancer ~ False Hope explains how high dose chemotherapy and bone marrow transplant (HDC-BMT) was blocked by insurers because there was not enough evidence to show an improved survival benefit. Leading oncologists promoted it because of improved progression free survival and overall response rate, and the patient was facing death.

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Evidence And Emotion: ‘Jumping The Gun’ On Treatment For ~ Treatment For Breast Cancer by Rick Mathis False Hope: Bone Marrow Transplanta- . in treating breast cancer. Although it is toxic, . with autologous bone marrow transplantation (HDC/ABMT) in .

The Controversy Over High-Dose Chemotherapy With ~ In the 1990s more than 41,000 patients underwent high-dose chemotherapy plus autologous bone marrow transplant (HDC-ABMT) for breast cancer, despite a paucity of clinical evidence of its efficacy.

High-dose chemotherapy and bone marrow transplant - Wikipedia ~ History. High-dose chemotherapy (HDC) with autologous bone marrow transplant (ABMT) was a treatment for advanced breast cancer developed in the 1980s, but the idea for HDC/ABMT was based on a previous leukemia treatment that emerged in the 1950s when E. Donnall Thomas had shown that bone marrow could be harvested from a person and transplanted into the same or another person.

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